BDBM476356 2-chlorophenyl (3S)-4-{3-cyclohexyl- N-[4-(hydroxymethyl)cyclohexyl]-D- alanyl}-3-[(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 12

SMILES O=C(NCc1cccs1)[C@@H]1CN(C(=O)Oc2ccccc2Cl)CCN1C(=O)[C@@H](CC1CCCCC1)NC1CCC(CO)CC1

InChI Key InChIKey=HHEVYYQFGIYJBS-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476356   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476356BDBM476356(2-chlorophenyl (3S)-4-{3-cyclohexyl- N-[4-(hydroxy...)
Affinity DataIC50: 26.6nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent