BDBM476379 4-(aminomethyl)-2-methoxyphenyl (3S)-4-(N,3-dicyclohexyl-D-alanyl)-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 35

SMILES COc1cc(CN)ccc1OC(=O)N1CCN([C@@H](C1)C(=O)NCc1cccs1)C(=O)[C@@H](CC1CCCCC1)NC1CCCCC1

InChI Key InChIKey=DIJMUIVXPUZBPH-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476379   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476379BDBM476379(4-(aminomethyl)-2-methoxyphenyl (3S)-4-(N,3-dicycl...)
Affinity DataIC50: 24.4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
US Patent