BDBM476395 1-chloronaphthalen-2-yl (3S)-4-[N-(4- aminocyclohexyl)-3-cyclohexyl-D- alanyl]-3-{[4-(aminomethyl)-3- methoxybenzyl]carbamoyl}piperazine- 1-carboxylate::US10875851, Example 51

SMILES COc1cc(CNC(=O)[C@@H]2CN(C(=O)Oc3ccc4ccccc4c3Cl)CCN2C(=O)[C@@H](CC2CCCCC2)NC2CCC(N)CC2)ccc1CN

InChI Key InChIKey=MTFKTKMIUQLBOP-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476395   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476395BDBM476395(1-chloronaphthalen-2-yl (3S)-4-[N-(4- aminocyclohe...)
Affinity DataIC50: 16.7nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
US Patent