BDBM476404 2-chlorophenyl (3S)-4-[(2R)-2- (cyclohexylamino)-2-{1-[(2- methylpropyl)sulfonyl]piperidin-4- yl}acetyl]-3-[(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 60

SMILES CC(C)CS(=O)(=O)N1CCC(CC1)[C@@H](NC1CCCCC1)C(=O)N1CCN(C[C@H]1C(=O)NCc1cccs1)C(=O)Oc1ccccc1Cl

InChI Key InChIKey=QAGPMJBCOFEWJR-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476404   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476404BDBM476404(2-chlorophenyl (3S)-4-[(2R)-2- (cyclohexylamino)-2...)
Affinity DataIC50: 22.6nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
US Patent