BDBM476412 2-chlorophenyl (3S)-4-{(2R)-2- (cyclohexylamino)-2-[1-(1,3-thiazol- 4-ylcarbonyl)piperidin-4-yl]acetyl}-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 68

SMILES Clc1ccccc1OC(=O)N1CCN([C@@H](C1)C(=O)NCc1cccs1)C(=O)[C@H](NC1CCCCC1)C1CCN(CC1)C(=O)c1cscn1

InChI Key InChIKey=SVBZRROGTKEKDL-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476412   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476412BDBM476412(2-chlorophenyl (3S)-4-{(2R)-2- (cyclohexylamino)-2...)
Affinity DataIC50: 15.7nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent