BDBM476424 4-(aminomethyl)naphthalen-1-yl (3S)- 4-[N2-(2-benzyl-2-azaspiro[4.5]dec-8- yl)-N6-(methylsulfonyl)-D-lysyl]-3- [(thiophen-2- ylmethyl)carbamoyl]piperazine-1- carboxylate::US10875851, Example 80

SMILES CS(=O)(=O)NCCCC[C@@H](NC1CCC2(CC1)CCN(Cc1ccccc1)C2)C(=O)N1CCN(C(=O)Oc2ccc(CN)c3ccccc23)C[C@H]1C(=O)NCc1cccs1

InChI Key InChIKey=ZIEWMOMSBMLBMV-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476424   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476424BDBM476424(4-(aminomethyl)naphthalen-1-yl (3S)- 4-[N2-(2-benz...)
Affinity DataIC50: 15.5nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent