BDBM476429 2-chlorophenyl (3S)-3-{[4- (aminomethyl)-3- methoxybenzyl]carbamoyl}-4-[N2-(2- benzyl-2-azaspiro[4.5]dec-8-yl)-N6- (methylsulfonyl)-D-lysyl]piperazine- 1-carboxylate::US10875851, Example 85

SMILES COc1cc(CNC(=O)[C@@H]2CN(C(=O)Oc3ccccc3Cl)CCN2C(=O)[C@@H](CCCCNS(C)(=O)=O)NC2CCC3(CC2)CCN(Cc2ccccc2)C3)ccc1CN

InChI Key InChIKey=VNENSVJXIXSOCA-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476429   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476429BDBM476429(2-chlorophenyl (3S)-3-{[4- (aminomethyl)-3- methox...)
Affinity DataIC50: 8.30nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent