BDBM476450 2-chloro-3,4-dimethylphenyl (3S)-3- {[4-(aminomethyl)-3- methoxybenzyl]carbamoyl}-4-[(2R)- 2- (cyclohexylamino)butanoyl]piperazine- 1-carboxylate::US10875851, Example 106

SMILES CC[C@@H](NC1CCCCC1)C(=O)N1CCN(C[C@H]1C(=O)NCc1ccc(CN)c(OC)c1)C(=O)Oc1ccc(C)c(C)c1Cl

InChI Key InChIKey=UCMDOAFSHLDCES-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476450   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476450BDBM476450(2-chloro-3,4-dimethylphenyl (3S)-3- {[4-(aminometh...)
Affinity DataIC50: 6.20nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent