BDBM476470 (2S)-1-[N2-cyclohexyl-N6- (methylsulfonyl)-D-lysyl]-4-(1-oxa-3- azaspiro[4.5]dec-2-en-2-yl)-N- (thiophen-2-ylmethyl)piperazine-2- carboxamide::US10875851, Example 126

SMILES CS(=O)(=O)NCCCC[C@@H](NC1CCCCC1)C(=O)N1CCN(C2=NCC3(CCCCC3)O2)C[C@H]1C(=O)NCc1cccs1

InChI Key InChIKey=CRSFQWAILFSKPV-UHFFFAOYSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476470   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476470BDBM476470((2S)-1-[N2-cyclohexyl-N6- (methylsulfonyl)-D-lysyl...)
Affinity DataIC50: 21.1nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent