BDBM476483 (2S)-N-(3-chlorobenzyl)-4-(4,4- dimethyl-5-phenyl-4,5-dihydro-1,3- oxazol-2-yl)-1-(N2,N2,N6,N6- tetramethyl-D-lysyl)piperazine-2- carboxamide::US10875851, Example 139

SMILES CN(C)CCCC[C@H](C(=O)N1CCN(C2=NC(C)(C)C(c3ccccc3)O2)C[C@H]1C(=O)NCc1cccc(Cl)c1)N(C)C

InChI Key InChIKey=HVJRYKZVMBNLCP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476483   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476483BDBM476483((2S)-N-(3-chlorobenzyl)-4-(4,4- dimethyl-5-phenyl-...)
Affinity DataIC50: 52.4nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent