BDBM476500 (2S)-N-(3-chlorobenzyl)-4-(4,4- dimethyl-5-phenyl-4,5-dihydro-1,3- oxazol-2-yl)-1-(6-piperidin-1-yl-D- norleucyl)piperazine-2-carboxamide::US10875851, Example 156

SMILES CC1(C)N=C(N2CCN(C(=O)[C@H](N)CCCCN3CCCCC3)[C@H](C(=O)NCc3cccc(Cl)c3)C2)OC1c1ccccc1

InChI Key InChIKey=CALSYGMYGLXIHX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476500   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476500BDBM476500((2S)-N-(3-chlorobenzyl)-4-(4,4- dimethyl-5-phenyl-...)
Affinity DataIC50: 52.3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent