BDBM476504 (2S)-N-(3-chlorobenzyl)-4-(4,4- dimethyl-5-phenyl-4,5-dihydro-1,3- oxazol-2-yl)-1-[N-(1-methylethyl)-6- piperidin-1-yl-D-norleucyl]piperazine- 2-carboxamide::US10875851, Example 160

SMILES CC(C)N[C@H](CCCCN1CCCCC1)C(=O)N1CCN(C2=NC(C)(C)C(c3ccccc3)O2)C[C@H]1C(=O)NCc1cccc(Cl)c1

InChI Key InChIKey=HLKRFJKTXMNNJU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476504   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476504BDBM476504((2S)-N-(3-chlorobenzyl)-4-(4,4- dimethyl-5-phenyl-...)
Affinity DataIC50: 13.8nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent