BDBM476524 (2S)-N-[4-(aminomethyl)benzyl]-1- [N-(1-methylethyl)-6-piperidin-1-yl- D-norleucyl]-4-[(4S,5S)-4-methyl-5- phenyl-4,5-dihydro-1,3-oxazol-2- yl]piperazine-2-carboxamide::US10875851, Example 180

SMILES CC(C)N[C@H](CCCCN1CCCCC1)C(=O)N1CCN(C2=N[C@@H](C)[C@H](c3ccccc3)O2)C[C@H]1C(=O)NCc1ccc(CN)cc1

InChI Key InChIKey=QZRMKHLTSVTEGO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476524   

TargetCoagulation factor XII(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 476524BDBM476524((2S)-N-[4-(aminomethyl)benzyl]-1- [N-(1-methylethy...)
Affinity DataIC50: 47.1nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIIa can be determined using a relevant purified serin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent