BDBM477275 5-chloro-2-(N-((1S,2R)-2-(3-ethyl-6-fluoro-2-methylphenyl)-1-(5- oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)propyl)sulfamoyl)benzamide::US10889555, Example 11::US11634395, Example 11

SMILES CCc1ccc(F)c([C@@H](C)[C@H](NS(=O)(=O)c2ccc(Cl)cc2C(N)=O)c2n[nH]c(=O)o2)c1C

InChI Key InChIKey=AEKXQBBAMWJLFH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 477275   

TargetMuscarinic acetylcholine receptor M1/M2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM477275(US10889555, Example 11 | 5-chloro-2-(N-((1S,2R)-2-...)
Affinity DataIC50: 180nMAssay Description:First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM477275(US10889555, Example 11 | 5-chloro-2-(N-((1S,2R)-2-...)
Affinity DataIC50: 180nMAssay Description:First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

LigandPNGBDBM477275(US10889555, Example 11 | 5-chloro-2-(N-((1S,2R)-2-...)
Affinity DataIC50: 180nMAssay Description:For measuring the inhibitory activity of the test compound against the RNR reaction, the method described in Cancer Research 64, 1-6 (2004) was refer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutical Co.

US Patent
LigandPNGBDBM477275(US10889555, Example 11 | 5-chloro-2-(N-((1S,2R)-2-...)
Affinity DataIC50: 180nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent