BDBM477458 US10889555, Example 230A::US11634395, Example 230A

SMILES C[C@@H]([C@H](NS(=O)(=O)c1ccc(F)c2[C@@H](O)CCOc12)c1n[nH]c(=O)o1)c1c(F)ccc(C)c1C

InChI Key InChIKey=UDXBARFJUKBPBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477458   

LigandPNGBDBM477458(US10889555, Example 230A | US11634395, Example 230...)
Affinity DataIC50: 120nMAssay Description:For measuring the inhibitory activity of the test compound against the RNR reaction, the method described in Cancer Research 64, 1-6 (2004) was refer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M1/M2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM477458(US10889555, Example 230A | US11634395, Example 230...)
Affinity DataIC50: 120nMAssay Description:First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandPNGBDBM477458(US10889555, Example 230A | US11634395, Example 230...)
Affinity DataIC50: 120nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent