BDBM480543 1-(3-(Difluoromethyl)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-5-yl)-5-fluoro-7-methyl-3-(tetrahydro-2H-pyran-4-yl)-7,8-dihydroimidazo[1,5-a]pyrazin-6(5H)-one::US10899769, Example 27

SMILES CN1Cc2c(nc(C3CCOCC3)n2C(F)C1=O)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)F

InChI Key InChIKey=GKBCFYUPFQGCJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480543   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480543BDBM480543(1-(3-(Difluoromethyl)-2-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 43nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480543BDBM480543(1-(3-(Difluoromethyl)-2-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 8.94E+3nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent