BDBM480605 1-(3-(1,3-dimethyl-1H- pyrazol-4-yl)isoquinolin-8- yl)-5,7-dimethyl-3- (tetrahydro-2H-pyran-4-yl)- 7,8-dihydroimidazo[1,5-a] pyrazin-6(5H)-one::US10899769, Example 87::US10899769, Example 88

SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-c1cn(C)nc1C

InChI Key InChIKey=WSOSPNZDGBUARC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 480605   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM480605(US10899769, Example 88 | 1-(3-(1,3-dimethyl-1H- py...)
Affinity DataIC50: 1nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM480605(US10899769, Example 88 | 1-(3-(1,3-dimethyl-1H- py...)
Affinity DataIC50: 77nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM480605(US10899769, Example 88 | 1-(3-(1,3-dimethyl-1H- py...)
Affinity DataIC50: 101nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandPNGBDBM480605(US10899769, Example 88 | 1-(3-(1,3-dimethyl-1H- py...)
Affinity DataIC50: 1.07E+4nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent