BDBM480619 1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquinolin-8-yl)-7- methyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5-a] pyrazin-6(5H)-one::US10899769, Example 98

SMILES CN1Cc2c(-c3c(F)ccc4cc(-c5cnn(C)c5)ncc34)nc(C3CCOCC3)n2CC1=O

InChI Key InChIKey=QVLBFEOPVJKLHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480619   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480619BDBM480619(US10899769, Example 98 | 1-(7-fluoro-3-(1-methyl- ...)
Affinity DataIC50: 282nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480619BDBM480619(US10899769, Example 98 | 1-(7-fluoro-3-(1-methyl- ...)
Affinity DataIC50: 2.50E+4nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent