BDBM480623 1-(7-fluoro-3-(2- methylthiazol-5- yl)isoquinolin-8-yl)-7- methyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5-a] pyrazin-6(5H)-one::US10899769, Example 102

SMILES Cc1ncc(-c2ccc3c(-c4nc(C5CCOCC5)n5c4CN(C)C(=O)C5)c(F)ccc3n2)s1

InChI Key InChIKey=KGSXJMNCNVAOOU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480623   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480623BDBM480623(US10899769, Example 102 | 1-(7-fluoro-3-(2- methyl...)
Affinity DataIC50: 49nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480623BDBM480623(US10899769, Example 102 | 1-(7-fluoro-3-(2- methyl...)
Affinity DataIC50: 2.13E+4nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent