BDBM480624 7-methyl-1-(3-(2- methylthiazol-5- yl)isoquinolin-8-yl)-3- (tetrahydro-2H-pyran-4-yl)- 7,8-dihydroimidazo[1,5-a] pyrazin-6(5H)-one::US10899769, Example 103

SMILES CN1Cc2c(nc(C3CCOCC3)n2CC1=O)-c1cccc2nc(ccc12)-c1cnc(C)s1

InChI Key InChIKey=HEDAYLPEZYYTEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480624   

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480624BDBM480624(US10899769, Example 103 | 7-methyl-1-(3-(2- methyl...)
Affinity DataIC50: 10nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent

TargetCREB-binding protein [1081-1197](Human)
University Of Texas

US Patent
LigandChemical structure of BindingDB Monomer ID 480624BDBM480624(US10899769, Example 103 | 7-methyl-1-(3-(2- methyl...)
Affinity DataIC50: 4.03E+3nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
US Patent