BDBM480630 5,7-dimethyl-1-(3-(1- methyl-1H-pyrazol-4- yl)isoquinolin-8-yl)-3- (tetrahydro-2H-pyran-4-yl)- 7,8-dihydroimidazo[1,5-a] pyrazin-6(5H)-one::US10899769, Example 109

SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1cccc2cc(ncc12)-c1cnn(C)c1

InChI Key InChIKey=FMFGVLUVPAHDDT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 480630   

TargetCREB-binding protein [1081-1197](Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM480630(5,7-dimethyl-1-(3-(1- methyl-1H-pyrazol-4- yl)isoq...)
Affinity DataIC50:  341nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Board of Regents, The University of Texas System

US Patent
LigandPNGBDBM480630(5,7-dimethyl-1-(3-(1- methyl-1H-pyrazol-4- yl)isoq...)
Affinity DataIC50:  2nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent