BDBM482794 3-(1-[(1R,4R,5S)-4-hydroxy-3,35-trimethylcyclohexyl]-2-{[4-(trifluoromethoxy)-phenyl]amino}-1H-benzimidazol-5-yl)propanoic acid::US10919862, Example 2-5

SMILES C[C@H]1C[C@H](CC(C)(C)[C@@H]1O)n1c(Nc2ccc(OC(F)(F)F)cc2)nc2cc(CCC(O)=O)ccc12

InChI Key InChIKey=BBMYLUZDKNJFQH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 482794   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM482794(US10919862, Example 2-5 | 3-(1-[(1R,4R,5S)-4-hydro...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human IDH1 R132H mutant heterodimer in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM482794(US10919862, Example 2-5 | 3-(1-[(1R,4R,5S)-4-hydro...)
Affinity DataIC50: 4.10E+3nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent