BDBM486386 3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidin-2-yl)-N-(3-methyl-1,1- dioxidotetrahydrothiophen-3-yl)-1H- indole-6-carboxamide (enantiomer B)::US10947222, Example 18-B

SMILES C[C@@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(cn(-c3ncc(F)cn3)c2c1)-c1cccc(OC(F)F)c1

InChI Key InChIKey=ATKVVVYTNAELOU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 486386   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486386(3-(3-(difluoromethoxy)phenyl)-1-(5- fluoropyrimidi...)
Affinity DataIC50: 0.910nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent