BDBM488246 2-(3-(4'-cyano-6-fluoro- [1,1'-biphenyl]-3-yl)-5- (cyclopropylmethyl)-4-(3-fluoro- 4-sulfamoylbenzyl)- 1H-pyrazol-1-yl)thiazole-4- carboxylic acid::US10954228, Compound 201::US11752138, Compound 201

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccc(cc2)C#N)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=ZTRNNCWPBDVQFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488246   

TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandChemical structure of BindingDB Monomer ID 488246BDBM488246(2-(3-(4'-cyano-6-fluoro- [1,1'-biphenyl]-3-yl)-5- ...)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandChemical structure of BindingDB Monomer ID 488246BDBM488246(2-(3-(4'-cyano-6-fluoro- [1,1'-biphenyl]-3-yl)-5- ...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent