BDBM488500 US20250092017, Compound P10

SMILES CC(C)c4ccc(N1CC(NC(=O)N(C)C)C1)c5cnc(Nc3ccnc(N2CCC(O)C(F)C2)n3)cc45

InChI Key InChIKey=IGQQTFWBDYSERA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 488500   

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 488500BDBM488500(US20250092017, Compound P10)
Affinity DataIC50: 0.560nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,C797S](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 488500BDBM488500(US20250092017, Compound P10)
Affinity DataIC50: 41nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 488500BDBM488500(US20250092017, Compound P10)
Affinity DataIC50: 43.2nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Puhe Biopharma Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 488500BDBM488500(US20250092017, Compound P10)
Affinity DataIC50: 100nMAssay Description:The MSA (Mobility Shift Assay) method was used to detect the effects of small molecule inhibitors on the kinase activity of EGFR wild type and its mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2025
Entry Details
US Patent