BDBM489092 2-(3-(3- cydopropoxy-4- fluorophenyl)-5- (cyclopropylmethyl)- 4-(3-fluoro-4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;::US10961200, Compound 471::US11247971, Cmpd ID 471

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(OC3CC3)c2)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=AOCZTOCUQOZJKJ-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 489092   

TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489092(US10961200, Compound 471 | 2-(3-(3- cydopropoxy-4-...)
Affinity DataKd:  0.00400nMAssay Description:Binding affinity to LDHA (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489092(US10961200, Compound 471 | 2-(3-(3- cydopropoxy-4-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489092(US10961200, Compound 471 | 2-(3-(3- cydopropoxy-4-...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489092(US10961200, Compound 471 | 2-(3-(3- cydopropoxy-4-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of LDHA in human A673 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489092(US10961200, Compound 471 | 2-(3-(3- cydopropoxy-4-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489092(US10961200, Compound 471 | 2-(3-(3- cydopropoxy-4-...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human LDHB using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed