BDBM489272 2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-[4-methyl-2-({6-[(5R)-5-methyl-2-oxopiperazin-1-yl]pyridin-2-yl}amino)-1,3-thiazol-5-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-sulfonamide::US10961236, Example 45

SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2C[C@@H](C)NCC2=O)nc1C

InChI Key InChIKey=YXGZTQDPLYDOCC-WBVHZDCISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489272   

LigandPNGBDBM489272(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-[4-methyl-2...)
Affinity DataIC50:  1nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489272(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-[4-methyl-2...)
Affinity DataIC50:  257nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489272(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-[4-methyl-2...)
Affinity DataIC50:  33nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489272(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-[4-methyl-2...)
Affinity DataIC50:  0.800nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent