BDBM489916 US10966980, Example 170

SMILES COc1cc(C)c(S(=O)(=O)C[C@H]2C[C@@H](N(C)c3ncnc4[nH]ccc34)C2)cn1

InChI Key InChIKey=FUEIJOICQSRCFR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489916   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 489916BDBM489916(US10966980, Example 170)
Affinity DataIC50: 0.00500nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 489916BDBM489916(US10966980, Example 170)
Affinity DataIC50: 0.113nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 489916BDBM489916(US10966980, Example 170)
Affinity DataIC50: 1.14nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 489916BDBM489916(US10966980, Example 170)
Affinity DataIC50: 7.53nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent