BDBM490310 US10968215, Compound 187

SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc2c(-c3cnc(C)nc3)ccn2c(C(C)N2CCN(CC(F)(F)F)CC2)c1C

InChI Key InChIKey=JKEFHMIKUJDKOO-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490310   

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Human)
Shanghai Haihe Pharmaceutical

US Patent

LigandBDBM490310(US10968215, Compound 187)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:EZH2Y641F: PRC2 complex experimental method: Experimental method: PRC2 complex (EZH2 Y641F/EED/SUZ12/RbAp48/AEBP2), H3(1-50) me1 substrate, methyl do...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/9/2021
Entry Details
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