BDBM490791 9-((4S,6R,7S,11aR,13R,14R,14aR,15R)-13-(6-amino-9H-purin-9-yl)-14-fluoro-15-hydroxy-2,9-dimercapto-2,9-disulfidooctahydro-11H-4,7-methanofuro[3,2-d][1,3,7,9]tetraoxa[2,8]diphosphacyclotridecin-6-yl)-1-methyl-1,9-dihydro-6H-purin-6-one (J-5)::US10968242, Example 18

SMILES Cn1cnc2n(cnc2c1=O)[C@@H]1C[C@@H]2OP(S)(=S)O[C@H]3[C@@H](F)[C@@H](O[C@@H]3COP(S)(=S)O[C@@H]1[C@@H]2O)n1cnc2c(N)ncnc12

InChI Key InChIKey=UIFNZLJEUSSYFS-UHFFFAOYSA-N

Data  1 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 490791   

TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490791(US10968242, Example 18 | 9-((4S,6R,7S,11aR,13R,14R...)
Affinity DataKi:  0.190nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490791(US10968242, Example 18 | 9-((4S,6R,7S,11aR,13R,14R...)
Affinity DataKd:  0.200nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

LigandPNGBDBM490791(US10968242, Example 18 | 9-((4S,6R,7S,11aR,13R,14R...)
Affinity DataKd:  1nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent