BDBM493001 5-((2-((tert-butyl(methyl)amino)methyl)-6-fluorobenzyl)amino)-6-cyclopropyl-3-fluoro-N-(thiazol-4-yl)pyridine-2-sulfonamide::US10981905, Example 49::US11639351, Example 49

SMILES CN(Cc1cccc(F)c1CNc1cc(F)c(nc1C1CC1)S(=O)(=O)Nc1cscn1)C(C)(C)C

InChI Key InChIKey=HLHOYXMAQZZRCQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 493001   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 78nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 78nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 3.75E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 3.75E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 7.50E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 7.50E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent