BDBM493045 US10981906, Example 145::cyclopropylmethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3- yl0amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate

SMILES O=C(CC#N)N1CCC[C@H](C1)Nc1c(cnc2[nH]ccc12)C(=O)OCC1CC1

InChI Key InChIKey=DEBDHSMBXWXDMI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493045   

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM493045(US10981906, Example 145 | cyclopropylmethyl (R)-4-...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM493045(US10981906, Example 145 | cyclopropylmethyl (R)-4-...)
Affinity DataIC50: 550nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent