BDBM493782 US10988459, Example 14

SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nn(C)c3CC[C@H](Cc23)C(F)(F)F)C1=O

InChI Key InChIKey=XYJCKGKOLPUUIN-YPMHNXCESA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 493782   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM493782(US10988459, Example 14)
Affinity DataKi:  63nMAssay Description:Inhibition of recombinant human His/GST-tagged RIPK1 (2 to 257 residues) expressed in insect expression system incubated for 2 hrs by fluorescence po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 1 [2-375](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM493782(US10988459, Example 14)
Affinity DataKi:  167nMAssay Description:The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1 [2-375](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM493782(US10988459, Example 14)
Affinity DataKi: >1.00E+4nMAssay Description:The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent