BDBM493883 US10988459, Example 81

SMILES CN1c2ccccc2OC[C@H](NC(=O)c2nnc3ccc(nn23)C(F)(F)F)C1=O

InChI Key InChIKey=RNTMSYICWDGEBC-VIFPVBQESA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493883   

TargetReceptor-interacting serine/threonine-protein kinase 1 [2-375](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM493883(US10988459, Example 81)
Affinity DataKi:  567nMAssay Description:The ability of the receptor interacting protein kinase (RIPK1) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) is monitored using...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM493883(US10988459, Example 81)
Affinity DataKi:  570nMAssay Description:Inhibition of recombinant human His/GST-tagged RIPK1 (2 to 257 residues) expressed in insect expression system incubated for 2 hrs by fluorescence po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed