BDBM497260 (4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(pyridin-4- yl)methanone::US11001586, Example 27

SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1

InChI Key InChIKey=DWFDADABQIDXBP-VJBMBRPKSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 497260   

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50: <3nMAssay Description:Activity Against Mer Tyrosine Kinase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50:  750nMAssay Description:Activity Against Tyro3 Tyrosine Kinase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50:  150nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50:  240nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50:  46nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497260((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed