BDBM498316 US11014911, Example 141::US11718603, Example 141

SMILES C[C@H]1CCCN1C(=O)O[C@@H]1CC[C@H](c2cc(NC(=O)Cc3cnc4ncnn4c3)n[nH]2)C1

InChI Key InChIKey=DFKIWZHPSTVGSR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 498316   

LigandChemical structure of BindingDB Monomer ID 498316BDBM498316(US11014911, Example 141 | US11718603, Example 141)
Affinity DataKi:  0.0800nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 498316BDBM498316(US11014911, Example 141 | US11718603, Example 141)
Affinity DataKi:  0.0800nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 498316BDBM498316(US11014911, Example 141 | US11718603, Example 141)
Affinity DataKi:  5.75nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 498316BDBM498316(US11014911, Example 141 | US11718603, Example 141)
Affinity DataKi:  5.75nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/15/2023
Entry Details
US Patent