BDBM499868 US11020398, Compound I-180::rac-(2-chloro-4-phenoxyphenyl)(4- (((1S,3R,4S)-3,4- dihydroxycyclohexyl)amino)-7H- pyrrolo[2,3-d]pyrimidin-5-yl)methanone

SMILES O[C@H]1CC[C@@H](C[C@H]1O)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12

InChI Key InChIKey=LXWLNOREYLZZOA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 499868   

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499868(rac-(2-chloro-4-phenoxyphenyl)(4- (((1S,3R,4S)-3,4...)
Affinity DataIC50: 1.80nMAssay Description:The active BTK assay consisted of phosphorylated form of full length BTK. The assay was performed in a buffer solution utilized in the inactive BTK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent