BDBM499976 (racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl)amino)methyl)pyrrolidin-1-yl)prop- 2-en-1-one::US11020398, Compound I-325r

SMILES Clc1cc(Oc2ccccc2)ccc1C(=O)c1c[nH]c2ncnc(NCC3CCCN3C(=O)C=C)c12

InChI Key InChIKey=LBAYNVWBJUCBJY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 499976   

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499976((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)
Affinity DataIC50: 0.980nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499976((racemic)-1-(2-(((5-(2-chloro-4- phenoxybenzoyl)-7...)
Affinity DataIC50: 136nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent