BDBM499991 US11020398, Compound I-360e::racemic-cis-(2-chloro-4- phenoxyphenyl)(4-(((6- (hydroxymethyl)-1-methylpiperidin-2- yl)methyl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5-yl)methanone

SMILES CN1[C@H](CO)CCC[C@@H]1CNc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12

InChI Key InChIKey=GBWYOPQZQJHQCS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 499991   

TargetTyrosine-protein kinase BTK(Human)
Arqule

US Patent
LigandPNGBDBM499991(racemic-cis-(2-chloro-4- phenoxyphenyl)(4-(((6- (h...)
Affinity DataIC50: 1.07nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Arqule

US Patent
LigandPNGBDBM499991(racemic-cis-(2-chloro-4- phenoxyphenyl)(4-(((6- (h...)
Affinity DataIC50: 59.4nMAssay Description:Purified full-length inactive BTK (wild type and C481 mutant, N-terminal 6XHIS tagged BTK, Mwt=78.2 kDa) were activated using soluble inositol hexaki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2021
Entry Details
US Patent