BDBM50004952 3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid::CHEMBL31344
SMILES OC(=O)CCc1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O
InChI Key InChIKey=KNBSYZNKEAWABY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50004952
Affinity DataKi: 140nMAssay Description:Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microMMore data for this Ligand-Target Pair
Affinity DataKi: 1.21E+3nMAssay Description:Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by homologous competition binding assay in presence o...More data for this Ligand-Target Pair
Affinity DataKi: 2.32E+3nMAssay Description:Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO-K1 cell membranes after 60 mins by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.45E+3nMAssay Description:Displacement of [3H]PSB-12150 from human GPR17 expressed in CHO cell membranes after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) Rosetta cells assessed as reduction of NADP+ to NADPH by phosphoglucose isom...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranesMore data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of FBPase (unknown origin)More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Chinese Academy of Medical Sciences & Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coup...More data for this Ligand-Target Pair
TargetUracil nucleotide/cysteinyl leukotriene receptor(Mouse)
Sultan Qaboos University
Curated by ChEMBL
Sultan Qaboos University
Curated by ChEMBL
Affinity DataEC50: 1.11E+3nMAssay Description:Agonist activity at mouse GPR17 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by calcium 5-dye based assayMore data for this Ligand-Target Pair
TargetUracil nucleotide/cysteinyl leukotriene receptor(Rat)
Sultan Qaboos University
Curated by ChEMBL
Sultan Qaboos University
Curated by ChEMBL
Affinity DataEC50: 705nMAssay Description:Agonist activity at rat GPR17 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by calcium 5-dye based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity of the compound against Fructose-1,6-bisphosphatase (F16BPase) in porcine kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...More data for this Ligand-Target Pair
Affinity DataKd: 1.26E+3nMAssay Description:Binding affinity to human GPR17 expressed in CHO-K1 cell membranes after 60 mins by saturation curve studyMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Rat)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Compound was evaluated for in vitro inhibition of cGMP cerebellar slice at NMDA receptor.More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranesMore data for this Ligand-Target Pair