BDBM50005866 2-{4-[(2-Amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-(ethoxy-hydroxy-phosphoryl)-butyric acid::CHEMBL294973

SMILES CCOP(O)(=O)CCC(NC(=O)c1ccc(NCc2cnc3nc(N)[nH]c(=O)c3c2)cc1)C(O)=O

InChI Key InChIKey=FBRKPFQSNPGVGM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50005866   

TargetDihydrofolate reductase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005866(CHEMBL294973 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThymidylate synthase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005866(CHEMBL294973 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataIC50: 1.00E+5nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mouse)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005866(CHEMBL294973 | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-py...)
Affinity DataKi:  2.00E+6nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed