BDBM50008003 CHEMBL4065924

SMILES Clc1ccc(cc1Cl)C(=O)NCC1NCCc2ccccc12

InChI Key InChIKey=QOBIYGABRBAJNZ-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50008003   

TargetMu-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50008003(CHEMBL4065924)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]naloxone from recombinant human MOR expressed in HEK cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50008003(CHEMBL4065924)
Affinity DataIC50: 230nMAssay Description:Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50008003(CHEMBL4065924)
Affinity DataEC50:  250nMAssay Description:Agonist activity at human MOR expressed in CHO-K1 cells co-expressing Galpha 15 assessed as increase in intracellular calcium release incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50008003(CHEMBL4065924)
Affinity DataIC50: 810nMAssay Description:Agonist activity at human KOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details Article
PubMed