BDBM50008765 CHEMBL3236638

SMILES CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](C[C@](C)(Cc2ccccc2)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=AWJWXXHHLFWIPR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50008765   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50008765BDBM50008765(CHEMBL3236638)
Affinity DataIC50: 7.60nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50008765BDBM50008765(CHEMBL3236638)
Affinity DataIC50: 137nMAssay Description:Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50008765BDBM50008765(CHEMBL3236638)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed