BDBM50009366 CHEMBL3233842::US11504364, Compound Ref.-Comp.::US9346814, Cmpd No 1, Example 1

SMILES FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12

InChI Key InChIKey=PUOOCZVRHBHJRS-NSHDSACASA-N

Data  29 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50009366   

TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  3.20nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresequence protease, mitochondrial(Homo sapiens (Human))
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  5.50E+3nMAssay Description:PREP enzymatic activity assay. To assay baseline prolyl endopeptidase (PREP) activity, 20 ng of recombinant human PREP (rhPREP) (R&S system, #4308-SE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.25E+4nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.80E+3nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.80E+3nMAssay Description:Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1(Rattus norvegicus)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  42nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate measured upto 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1(Rattus norvegicus)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  55nMAssay Description:Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1(Rattus norvegicus)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of FAP (unknown origin) using AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP4 (unknown origin) using AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of PREP (unknown origin) using AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DPP2 (unknown origin) using AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of DPP9 (unknown origin) using AMC substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1(Rattus norvegicus)
Peking University First Hospital

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of SF-tagged FAP (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of SF-tagged DPP4 (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast activation protein(Rat)
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:FAPα enzymatic exopeptidase (dipeptidase) activity assay. To assay baseline FAPa enzymatic exopeptidase activity, 40 ng of recombinant human FAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:FAPα enzymatic exopeptidase (dipeptidase) activity assay. To assay baseline FAPa enzymatic exopeptidase activity, 40 ng of recombinant human FAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Mus musculus)
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:DPPIV enzymatic activity assay. To assay baseline dipeptidyl peptidase-4 (DPPIV) activity, 40 ng of recombinant human DPPIV (rhDPPIV) (R&S system, #1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:DPPIV enzymatic activity assay. To assay baseline dipeptidyl peptidase-4 (DPPIV) activity, 40 ng of recombinant human DPPIV (rhDPPIV) (R&S system, #1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresequence protease, mitochondrial(Mouse)
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:PREP enzymatic activity assay. To assay baseline prolyl endopeptidase (PREP) activity, 20 ng of recombinant human PREP (rhPREP) (R&S system, #4308-SE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPresequence protease, mitochondrial(Homo sapiens (Human))
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  5.50E+3nMAssay Description:PREP enzymatic activity assay. To assay baseline prolyl endopeptidase (PREP) activity, 20 ng of recombinant human PREP (rhPREP) (R&S system, #4308-SE...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  5.50E+3nMAssay Description:DPP9 enzymatic activity assay. To assay baseline dipeptidyl peptidase 9 (DPP9) activity, 40 ng of recombinant human DPP9 (rhDPP9) (R&S system, #5419-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Praxis Biotech

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:FAPα enzymatic exopeptidase (dipeptidase) activity assay. To assay baseline FAPa enzymatic exopeptidase activity, 40 ng of recombinant human FAP...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Universiteit Antwerp

US Patent
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50:  5.50E+3nMAssay Description:DPP9 enzymatic activity assay. To assay baseline dipeptidyl peptidase 9 (DPP9) activity, 40 ng of recombinant human DPP9 (rhDPP9) (R&S system, #5419-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: <1.00E+3nMAssay Description:DPPIV enzymatic activity assay. To assay baseline dipeptidyl peptidase-4 (DPPIV) activity, 40 ng of recombinant human DPPIV (rhDPPIV) (R&S system, #1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50009366(CHEMBL3233842 | US11504364, Compound Ref.-Comp. | ...)
Affinity DataIC50: >1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails US Patent