BDBM50010858 1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)cyclohexanol::1-[1-(3-Chloro-phenyl)-2-dimethylamino-ethyl]-cyclohexanol (HCl)::CHEMBL101899

SMILES CN(C)CC(c1cccc(Cl)c1)C1(O)CCCCC1

InChI Key InChIKey=ZUFCXVFSSJFSOT-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50010858   

TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 121nMAssay Description:Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 130nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 160nMAssay Description:Inhibition of norepinephrine uptake at rat brain norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTransporter(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 160nMAssay Description:Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 292nMAssay Description:Inhibition of 5HT uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 320nMAssay Description:Inhibition of 5HT uptake at rat brain SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50010858(CHEMBL101899 | 1-[1-(3-Chloro-phenyl)-2-dimethylam...)
Affinity DataIC50: 320nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed