BDBM50011278 CHEMBL3260356::US10696692, Example 269

SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CC2(C1)CCOCC2)c1cnc2[nH]ncc2c1

InChI Key InChIKey=KIPXYZGQWPQZCV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50011278   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011278(CHEMBL3260356 | US10696692, Example 269)
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50011278(CHEMBL3260356 | US10696692, Example 269)
Affinity DataIC50: 113nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent