BDBM50012638 CHEMBL3261052

SMILES [H][C@@]12CC(F)(F)C[C@]1([H])[C@](C)(N=C(N)O2)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=MCSRMJYZOOAQPY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50012638   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012638(CHEMBL3261052)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing APP695 assessed as inhibition of amyloid beta (1 to 40) production after 18 to 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed