BDBM50015088 (E)-N-Hydroxy-3-phenyl-acrylamide::(E)-N-Hydroxy-3-phenylacrylamide::CHEMBL154574::N-Hydroxy-3-phenyl-acrylamide::US10188756, Compound CN86::trans-N-Hydroxy-3-phenyl-acrylamide

SMILES ONC(=O)\C=C\c1ccccc1

InChI Key InChIKey=UVDDFTZLVFIQFL-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50015088   

TargetHistone deacetylase 6(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 21.7nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 22nMT: 2°CAssay Description:Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 133nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 3(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 151nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 457nMT: 2°CAssay Description:Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Broad Institute of Mit and Harvard

Curated by ChEMBL
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 470nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 725nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 759nMT: 2°CAssay Description:Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 1.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 1.20E+4nMAssay Description:Compound was tested for its in vitro inhibitory activity against RBL-1 5-LO (time dependent)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 1.20E+4nMAssay Description:Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 1.95E+4nMT: 2°CAssay Description:Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 2.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
The General Hospital

US Patent
LigandPNGBDBM50015088((E)-N-Hydroxy-3-phenylacrylamide | CHEMBL154574 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent