BDBM50018154 3-Isobutyl-1-(3-methyl-butyl)-3,7-dihydro-purine-2,6-dione::CHEMBL20613

SMILES CC(C)CCn1c(=O)n(CC(C)C)c2nc[nH]c2c1=O

InChI Key InChIKey=HRWQHFZQHIUCCC-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50018154   

TargetAdenosine receptor A1(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes & Digestive & Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi:  6.24E+3nMAssay Description:Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Pharmazeutische Chemie

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi:  1.30E+4nMAssay Description:Antagonism of binding of 1 nM [3H]cyclohexyladenosine to adenosine A1 receptors on rat cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity at A1 adenosine receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50018154(CHEMBL20613 | 3-Isobutyl-1-(3-methyl-butyl)-3,7-di...)
Affinity DataKi: >1.50E+5nMAssay Description:Antagonism of cyclic [3H]AMP accumulation elicited by 15 uM 2-chloroadenosine in [3H]adenine-labeled guinea pig cerebral cortical slices at A2 recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed