BDBM50020565 CHEMBL2392188

SMILES COc1cc(/C=C/C(=O)/C=C/c2cc(CC=C(C)C)c(O)c(OC)c2)cc(CC=C(C)C)c1O

InChI Key InChIKey=AGFUAPYONOPZQE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50020565   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020565BDBM50020565(CHEMBL2392188)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020565BDBM50020565(CHEMBL2392188)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells preincubated for 15 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020565BDBM50020565(CHEMBL2392188)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
University Jena

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020565BDBM50020565(CHEMBL2392188)
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed